Dietary Interventions to Extend Life Span and Health Span Based on Calorie Restriction
نویسندگان
چکیده
منابع مشابه
Long-lived Indy and calorie restriction interact to extend life span.
Calorie restriction (CR) improves health and extends life span in a variety of species. Despite many downstream molecules and physiological systems having been identified as being regulated by CR, the mechanism by which CR extends life span remains unclear. The Drosophila gene Indy (for I'm not dead yet), involved in the transport and storage of Krebs cycle intermediates in tissues important in...
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Caloric restriction (CR), a reduction of food intake while avoiding malnutrition, can delay the onset of cancer and age-related diseases in several species, including mice. In addition, depending of the genetic background, CR can also increase or decrease mouse longevity. This has highlighted the importance of identifying the molecular pathways that interplay with CR in modulating longevity. Si...
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Calorie Restriction (CR) is a defined intervention tool currently being studied as an effort to achieve numerous health benefits and increase longevity. Currently, there is a large body of research that indicates a multitude of health benefits and positive associations; however, there is also a plethora of opposing research. Through investigation of epigenetics, the efficacy of calorie restrict...
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E vidence that calorie restriction (CR) retards aging and extends median and maximal life span was fi rst described in the 1930s by McCay et al. [1]. Since then, similar observations have been made in a variety of species including rodents, fi sh, fruit fl ies, worms, and yeast [2]—and although they are not yet defi nitive, results from ongoing longevity studies in monkeys suggest that CR will ...
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Calorie restriction slows aging and increases life span in many organisms. In yeast, a mechanistic explanation has been proposed whereby calorie restriction slows aging by activating Sir2. Here we report the identification of a Sir2-independent pathway responsible for a majority of the longevity benefit associated with calorie restriction. Deletion of FOB1 and overexpression of SIR2 have been p...
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ژورنال
عنوان ژورنال: The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
سال: 2010
ISSN: 1079-5006,1758-535X
DOI: 10.1093/gerona/glq042